The liver is the largest organ in the body located on the right side behind the rib cage. The Liver holds 13% of the body’s blood supply. It performs several important functions of the body viz. convert food into energy, regulating blood clotting, making bile, and breaking down toxic substances such as drugs and alcohol. The liver is ideal for storing important substances like vitamins and minerals. It acts as a filter, removing impurities from the blood.
Some medications help treat the symptoms of liver failure, but there are no drugs that “cure” liver failure. If the liver begins to fail, the person may be eligible for a liver transplant.
The liver may become damaged as a result of illness, infection or alcohol. This damage causes the liver to become scarred, which is known as cirrhosis. Once cirrhosis reaches a certain level, the liver gradually loses all of its functions. This is known as liver failure, or end-stage liver disease (ESLD).
Liver Transplant procedure is a life saving operation in which usually a part of the diseased liver is replaced wholly or partially by a healthy liver. This may also be done in cases where the liver is functioning poorly.
Liver transplant centers match donors with recipients based on compatible liver size and blood type.
Other diseases that may progress to liver transplant include, but are not limited to, the following:
- Acute hepatic necrosis When tissue in liver become dead.
- Biliary duct atresia Absent or abnormally developed bile duct.
- Metabolic disease. Conditions that affect the chemical activity in cells that are affected by the liver.
- Liver cancers. Tumor developed inside the liver.
- Autoimmune hepatitis. Liver cell damage and destruction due to chronic inflammation in liver
Liver transplantation is a viable treatment option for end-stage liver disease and acute liver failure. A liver transplant is a surgical process in which diseased liver is replaced with a healthy liver. It is the second most commonly transplanted major organ after kidney.
Orthotropic liver transplant procedure in which the diseased liver is removed and healthy liver is transplanted on same location.
IMPORTANT: Patients having a history of Hepatitis, Cancer, Heart Disease, Lung Disease, and Infection are unsuitable for both – donor as well as recipient.
Types of donors
- Living Donor- Is a living and active person, who is a blood relative, friend or spouse. Donor health must be stable enough to undergo transplantation with excellent chances of success.
- Cadaveric Donor- Is a brain dead person but the heart is alive and patient is on advanced life support system.
The Donor needs to undergo some tests to make sure that the tissue type and the blood type must be compatible with the recipient. This reduces the chances of rejection of the organ by the body.
Liver donor Requirements / Criteria
- Good health
- Between 18-60 year old
- Liver size must be similar or bigger size than the recipient.
- Blood type should be same or compatible with recipient
- Donor must undergo some test.
Liver rejection may happen anytime after the transplant.
- Hyperacute Rejection:This may happen within a few minutes to a few hours after the transplant has been done. It is caused by anti donor antibodies which are performed and characterized by the binding of these to antigens on vascular endothelial cells.
- Acute Rejection: This does not happen immediately after transplant but after days or weeks of the procedure. It is the primary and most common target of the immunosuppressive agents.
- Chronic Rejection After one year of surgery any signs or symptoms are indicative of chronic rejection.
The Donor and Recipient both need to undergo through evaluation and investigations conducted by a team of highly qualified and experienced doctors. The Donor needs special attention to ensure he/she is perfectly healthy at the time of donation and continues with normal life after donation too. The recipient needs to be brought to an optimal state to withstand such a major surgery.
After surgery the patient needs to be kept in a special post transplant unit with specialized nursing care to ensure no infection takes place. Anti rejection injections may be given to ensure the body accepts the new organ and minimize risk of failure.
To know more about our Liver Transplant packages, call us at +91-9810085065 or mail us at email@example.com. We will be happy to provide any medical assistance.