In some males the sperm count or quality is very low or sometimes even nil, therefore they would not succeed with IVF which requires normal semen parameters. To achieve fertilization the egg is injected with single sperm and this technique is called Intracytoplasmic sperm injection (ICSI).ivf (2)

The common indications for doing ICSI are:-

  • Couples who have had unexplained fertilization failure in a previous IVF cycle
  • Low sperm count
  • Decreased sperm motility, including totally immotile sperm (e.g. Kartagener’s syndrome), providing sperm are viable.
  • Unusually high percentage of morphologically abnormal sperm, including round- headed sperm (globozoospermia).
  • Obstructive azoospermia caused by conditions such as congenital absence of the vas deferens (CAVD), post-inflammatory obstruction of the epididymis or vas and failed vasectomy reversal. Testicular sperm extraction (TESE) is used to retrieve sperm for ICSI.
  • Complete absence of sperm in the ejaculate due to defective sperm production (non- obstructive azoospermia). Patients who have normal sperm formation in at least some areas of the testis (identified by testicular biopsy), providing enough viable sperm can be retrieved with TESE.
  • Ejaculatory dysfunction caused by retrograde ejaculation (enough sperm are usually recovered from the urine) or paraplegia (electroejaculation or TESE).
  • Immunological factors; antisperm antibodies in female sera, follicular fluid or on sperm caused by vasectomy or genital tract infection.
  • Testicular cancer patients with semen samples frozen prior to treatment.

Intra Uterine Insemination (IUI)

IUI is perhaps the simplest treatment for infertility offered to all couples who have no other contraindication to it. It involves a laboratory procedure to separate fast moving sperm from more sluggish or non-moving sperm. The fast moving sperm are then placed into the woman’s womb close to the time of ovulation when the egg is released from the ovary.


Indications of IUI

  • There is unexplained infertility
  • There are ovulation problems
  • The male partner experiences impotence or premature ejaculation and sperm count is normal.
  • The male partner has azoospermia, when insemination is done using donor sperms.

Prerequisites to doing an IUI

  • Atleast 1 fallopian tube should be open as checked by hysterosalpingography or laparoscopy.
  • Normal or atleast near normal sperm count.

Success rates- IUI is a process with limited success rates with maximum chances of success being in the range of 10- 15%.

When to shift for IVF- The recommendation is to shift to IVF after 4 cycles of IUI.


To know more about our ICSI / IUI treatment packages, call us at +91-9810085065 or mail us at We will be happy to provide any medical assistance.